ABSTRACT
Background: The use of assisted reproductive technology [ART] is increasing in the world. The rate, efficacy and safety of ART are very different among countries. There is an increase in the use of intra cytoplasmic sperm injection [ICSI], single fresh embryo transfer [ET] and frozen-thawed embryo transfer [FET]
Objective: The objective of this study was to compare pregnancy rate in fresh ET and FET
Materials and Methods: In this retrospective cross-sectional study 1014 ICSI-ET cycles [426 fresh ET and 588 FET] from 753 women undergoing ICSI treatment referred to Fatemezahra Infertility and Reproductive Health Research Center in Babol, Iran from 2008 to 2013 were reviewed
Results: There were no significant differences between biochemical pregnancy rate [23% versus 18.8%, OR 1.301; 95% CI .95-1.774], gestational sac [95.6% versus 100% in FET, OR 0.60; 95% CI 0.54-0.67], and fetal heart activity [87.2% versus 93.6% OR .46; 95% CI .16-1.32] in fresh ET and FET cycles, respectively. P< 0.05 was considered statistically significant for all measures
Conclusion: Although, the result showed no significantly difference between the fresh ET and the FET cycles, however the embryos are able to be stored for subsequent ART. Therefore, we recommend FET cycles as an option alongside the fresh ET
ABSTRACT
This study was designed to investigate the effect of metformin and flutamide alone or in combination with anthropometric indices and laboratory tests of obese/overweight PCOS women under hypocaloric diet. This single blind clinical trial was performed on 120 PCOS women. At the beginning, hypocaloric diet was recommended for the patients. After one month while they were on the diet, the patients were randomly divided in 4 groups; metformin [500 mg, 3/day], flutamide [250 mg, 2/day], combined, metformin [500 mg, 3/day] with flutamide [250 mg, 2/day] and finally placebo group. The patients were treated for 6 months. Anthropometric indices and laboratory tests [fasting and glucose-stimulated insulin levels, lipid profile and androgens] were measured. A one-way ANOVA [Post Hoc] and paired t-test were performed to analyze data. A p